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KMID : 1134820180470090947
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 9 p.947 ~ p.951
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Characterization of Anti-Diabetic Complication Constituents from Oenanthe javanica
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Jeong Gyeong-Han
Kim Tae-Hoon
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Abstract
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Bioactivity-guided isolation was conducted on a ethyl acetate (EtOAc)-soluble portion of an aqueous ethanolic extract from Oenanthe javanica using an advanced glycation end products (AGEs) formation inhibition assay. The experiments led to isolation of four previously characterized flavonoids, hyperoside (1), isorhamnetin 3-O-galactoside (2), isorhamnetin (3), and persicarin (4). The structures were established on the basis of NMR and MS spectroscopic data interpretations. Among these isolated compounds, hyperoside (1) and isorhamnetin 3-O-galactoside (2) showed significant inhibitory effects against AGEs formation, with IC50 values of 28.7±1.3 and 41.5±2.5 μM, respectively. Furthermore, all tested compounds were evaluated for radical scavenging activity using hydroxyl radicals, and compounds 1 and 2 exhibited the most potent capacities. These results suggest that the flavonoids isolated from O. javanica might be beneficial for the prevention and treatment of diabetic complications and related diseases.
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KEYWORD
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Oenanthe javanica, advanced glycation end products, hydroxyl radical, flavonoids, diabetic complications
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